Resources (1-3 of 3)

1. Modeling a seeded continuous crystallizer for the production of active pharmaceutical ingredients

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   09 Jun 2023 | Contributor(s):: Besenhard, M. O., Hohl, R. Hodzic, A. Eder, R. J.P., Khinast, J. G.

   The approximation of a well mixed reactor is prevalent when it comes to the modeling of a crystallization process. Since temperature, concentration, and mass content vary due to inhomogeneous mixing, this approximation is a very loose one. The continuously operated seeded tubular crystallizer...

2. Control of Batch and Continuous Crystallization Processes using Reinforcement Learning

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   09 Jun 2023 | Contributor(s):: Benyahia, Brahim, Anandan, Paul Danny Rielly, Chris Türkay, Metin, Gani, Rafiqul

   In crystallization processes, the control of particle size distribution, shape and purity are crucial to achieve the targeted critical quality attributes of the final drug product and meet the pharmaceutical regulatory requirements. This work presents novel optimal trajectory tracking control...

3. Advanced control of a continuous oscillatory flow crystalliser

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   09 Jun 2023 | Contributor(s):: Tahir, F, Krzemieniewska-Nandwani, KMack, J, Lovett, D, Siddique, H, Mabbott, F, Raval, V, Houson, I, Florence, A

   This paper presents the application and challenges of achieving Model Predictive Control (MPC) on two continuous oscillatory baffled crystallisation reactors, delivering precise product quality control in the face of raw material fluctuations. A key advantage of MPC is that it effectively deals...