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Tags: tablet compaction

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  1. The reality of in-line tablet coating

    Contributor(s):: Cahyadi, Christine, Chan, Lai Wah, Heng, Paul Wan Sia

    The possibility of continuous processing in pharmaceutical tablet manufacturing is hampered by the viscoelastic recovery of tablets post-compaction. Compacted tablets are typically aged before coating to allow complete viscoelastic recovery so as to avoid subsequent coating defects. There has...

  2. Effects of process parameters on tablet critical quality attributes in continuous direct compression: a case study of integrating data-driven statistical models and mechanistic compaction models

    Contributor(s):: Huang, Zhuangrong, Galbraith, Shaun C., Cha, Bumjoon, Liu, Huolong, Park, Seoyoung, Flamm, Matthew H., Metzger, Matt, Tantuccio, Anthony, Yoon, Seongkyu

    Continuous manufacturing of oral-dosage drug products is increasing the need for rigorous process understanding both from a process design and control perspective. The purpose of this study is to develop a methodology that analyzes the effects of upstream process parameters on continuous tablet...