Skip to main content
Join CMKC members for a complimentary virtual event on December 10, 11am ET: CM MythBusters: https://bit.ly/3YXJynA. This is a fantastic opportunity to connect, collaborate, and debunk common myths about continuous manufacturing!
13.59.92.247

Tags: Tablet manufacturing

All Categories (1-5 of 5)

  1. Pharmaceutical application of multivariate modelling techniques: a review on the manufacturing of tablets

    09 Jun 2023 | Contributor(s):: Shi, Guolin, Lin, Longfei, Liu, Yuling, Chen, Gongsen, Luo, Yuting, Wu, Yanqiu, Li, Hui

    The tablet manufacturing process is a complex system, especially in continuous manufacturing (CM). It includes multiple unit operations, such as mixing, granulation, and tableting. In tablet manufacturing, critical quality attributes are influenced by multiple factorial relationships between...

  2. Model-predictive design, control and optimization of pharmaceutical process

    09 Jun 2023 | Contributor(s):: Muzzio, F, Singh, R Chaudhury, A Rogers, A Ramachandran, R, Ierapetritou, M

    Applying model-predictive methods and a continuous process-control framework to a continuous tablet-manufacturing process. Currently, there is a high level of interest in the pharmaceutical industry in continuous-manufacturing strategies, integrated with online-monitoring tools, that are...

  3. Blend Segregation in Tablets Manufacturing and Its Effect on Drug Content Uniformity-A Review

    09 Jun 2023 | Contributor(s):: Jakubowska, E, Ciepluch, N

    Content uniformity (CU) of the active pharmaceutical ingredient is a critical quality attribute of tablets as a dosage form, ensuring reproducible drug potency. Failure to meet the accepted uniformity in the final product may be caused either by suboptimal mixing and insufficient initial blend...

  4. Advanced Control of Continuous Pharmaceutical Tablet Manufacturing Processes

    09 Jun 2023 | Contributor(s):: Singh, Ravendra, Velazquez, Carlos Sahay, Abhishek Karry, Krizia M Muzzio, Fernando J Ierapetritou, Marianthi G, Ramachandran, Rohit

    A novel manufacturing strategy based on continuous processing, integrated with online/inline monitoring tools, coupled with an advanced automatic feedback control system is highly desired for efficient Quality by Design (QbD)-based manufacturing of the next generation of pharmaceutical products...

  5. A quality by design approach to investigate the effect of mannitol and dicalcium phosphate qualities on roll compaction

    09 Jun 2023 | Contributor(s):: Souihi, Nabil, Dumarey, Melanie, Wikstrom, Hakan, Tajarobi, Pirjo, Fransson, Magnus, Svensson, Olof, Josefson, Mats, Trygg, Johan

    Roll compaction is a continuous process for solid dosage form manufacturing increasingly popular within pharmaceutical industry. Although roll compaction has become an established technique for dry granulation, the influence of material properties is still not fully understood. In this study, a...