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Tags: tablet press

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  1. Monitoring the concentration of flowing pharmaceutical powders in a tableting feed frame

    09 Jun 2023 | Contributor(s):: Gosselin, Ryan, Durão, Pedro, Abatzoglou, Nicolas, Guay, Jean-Maxime

    The use of process analytical technology (PAT) tools is increasing steadily in the pharmaceutical industry. Such tools are now located throughout the process. When producing tablets, the tableting step itself may be the ideal moment to assess final product composition. Being the last unit...

  2. Development of a tablet press feed frame lead lag determination model using in-line and off-line NIR measurements

    09 Jun 2023 | Contributor(s):: Van;Hauwermeiren, D, Peeters, MPeeters, E, Cogoni, G, Yang, LA, De;Beer, T

    For continuous pharmaceutical manufacturing of oral solid dosages, it is essential that product quality is measured inline. In this application, a continuous rotary tablet press is used. The goal is a model-based assessment of the quality of the blend in the feed frame to determine whether the...

  3. Data reconciliation in the Quality-by-Design (QbD) implementation of pharmaceutical continuous tablet manufacturing

    09 Jun 2023 | Contributor(s):: Su, Qinglin, Bommireddy, Yasasvi, Shah Yash, Ganesh, Sudarshan, Moreno, Mariana, Liu, Jianfeng, Gonzalez, Marcial, Yazdanpanah, Nima, O'Connor, Thomas, Reklaitis, Gintaras V., Nagy, Zoltan K

    Data provided by in situ sensors is always affected by some level of impreciseness as well as uncertainty in the measurements due to process operation disturbance or material property variance. In-process data precision and reliability should be considered when implementing active product quality...

  4. Advanced Model Predictive Feedforward/Feedback Control of a Tablet Press

    09 Jun 2023 | Contributor(s):: Haas, Nicholas Townsend, Ierapetritou, Marianthi, Singh, Ravendra

    In continuous pharmaceutical manufacturing, real-time precise control of critical quality attributes (CQAs) is necessary for quality by design (QbD)-based manufacturing and real-time release (RTR) with minimum consumption of time, space, and resources. Pharmaceutical tablets can be produced...

  5. A Validated Model for Design and Evaluation of Control Architectures for a Continuous Tablet Compaction Process

    09 Jun 2023 | Contributor(s):: Nunes de Barros, Fernando, Bhaskar, Aparajith, Singh, Ravendra

    The systematic design of an advanced and efficient control strategy for controlling critical quality attributes of the tablet compaction operation is necessary to increase the robustness of a continuous pharmaceutical manufacturing process and for real time release. A process model plays a very...