Investigating the Effect of APAP Crystals on Tablet Behavior Manufactured by Direct Compression
Contributor(s):: Ghazi, Nastaran, Liu, Zhanjie, Bhatt, Chinmay, Kiang, San, Cuitino, Alberto
In this work, the effect of API's (Active Pharmaceutical Ingredient) shape and size on tablet characteristics is investigated for high API dose formulation manufactured by direct compression. Three different classes of APAP (acetaminophen) are selected, and tablets are produced in both single and...
A systematic study of the impact of changes of roller compactor equipment on granule and tablet properties
Contributor(s):: Haeffler, Gunnar, Schmidt, Leonard, Lakio, Satu, Reynolds, Gavin, Odman, Jonas, Tajarobi, Pirjo
Typical industrial development of roller compaction processes include changes in scale from laboratory to pilot and then further to production scale and also changes in equipment design due to equipment availability in different manufacturing facilities. Transfer and scale-up of roller compaction...