Route Optimization and Synthesis of Taxadienone
Contributor(s):: Krasutsky, Sergiy G., Jacobo, Sheila H., Tweedie, Scott R., Krishnamoorthy, Ravi, Filatov, Alexander S.
Early process development toward the scalable production of taxadienone on a decagram scale is described. A continuous flow reactor was employed to safely run a potentially hazardous cyclopropane ring opening. The route featured two copper-mediated additions, a Diels–Alder reaction and a...