Continuous Manufacturing Knowledge Center
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Design Space Identification and Visualization for Continuous Pharmaceutical Manufacturing
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09 Jun 2023 | Contributor(s):: Diab, S, Gerogiorgis, DI
Progress in continuous flow chemistry over the past two decades has facilitated significant developments in the flow synthesis of a wide variety of Active Pharmaceutical Ingredients (APIs), the foundation of Continuous Pharmaceutical Manufacturing (CPM), which has gained interest for its...
Biocatalytic Continuous Manufacturing of Diabetes Drug: Plantwide Process Modeling, Optimization, and Environmental and Economic Analysis
09 Jun 2023 | Contributor(s):: Ho, CH, Yi, JR, Wang, XN
This work proposes a comprehensive framework of biocatalytic continuous manufacturing of sitagliptin, the active pharmaceutical ingredient of the leading dipeptidyl peptidase-4 inhibitor antidiabetic drug. Continuous manufacturing has the advantages of quality consistency, reduced waste...