Evolution of flow-oriented design strategies in the continuous preparation of pharmaceuticals
09 Jun 2023 | Contributor(s):: Fulop, Z, Szemesi, PBana, P, Eles, J, Greiner, I
The dynamic progress in the multi-step continuous-flow synthesis of active pharmaceutical ingredients is part of the current industrial revolution. The recently implemented examples are the forerunners of safer and more sustainable pharmaceutical manufacturing. These systems utilize...
Continuous Single-Step Wet Granulation with Integrated in-Barrel-Drying
09 Jun 2023 | Contributor(s):: Schmidt, Adrian, de Waard, Hans, Kleinebudde, Peter, Krumme, Markus
Purpose It was investigated if continuous wet granulation and drying could be combined in a twin-screw granulator with the aimto provide (pre-) dried granules in a single-step process, i.e. in-barrel-drying. Methods To have a consistent and robust material propulsionmechanism, a twin-screw...