Native starch as in situ binder for continuous twin screw wet granulation
Contributor(s):: Vandevivere, Lise, Portier, Christoph, Vanhoorne, Valerie, Hausler, Olaf, Simon, Denis, De Beer, Thomas, Vervaet, Chris
The use of native starch as in situ binder in a continuous twin screw wet granulation process was studied. Gelatinization of pea starch occurred in the barrel of the granulator using a poorly soluble excipient (anhydrous dicalcium phosphate), but the degree of gelatinization depended on the...
Model-based analysis of high shear wet granulation from batch to continuous processes in pharmaceutical production - A critical review
Contributor(s):: Kumar, Ashish, Gernaey, Krist V., De Beer, Thomas, Nopens, Ingmar
The manufacturing of pharmaceutical dosage forms, which has traditionally been a batch-wise process, is now also transformed into a series of continuous operations. Some operations such as tabletting and milling are already performed in continuous mode, while the adaptation towards a complete...