Machine learning framework for extracting micro-viscoelastic and micro-structural properties of compressed oral solid dosage forms
23 Jul 2024 | Contributor(s):: Sultan, Tipu, Rozin, Enamul Hasan, Paul, Shubhajit, Tseng, Yin-Chao, Cetinkaya, Cetin
A compressed pharmaceutical oral solid dosage (OSD) form is a strongly micro-viscoelastic material composite arranged as a network of agglomerated particles due to its constituent powders and their bonding and fractural mechanical properties. An OSD product's Critical Quality Attributes, such as...
Micro-viscoelastic characterization of compressed oral solid dosage forms with ultrasonic wave dispersion analysis
23 Jul 2024 | Contributor(s):: Sultan, Tipu, Paul, Shubhajit, Rozin, Enamul Hasan, Tseng, Yin-Chao, Bazzocchi, Michael C. F., Cetinkaya, Cetin
Due to their constituent powders, the materials of advanced compressed oral solid dosage (OSD) forms are micro-composites and strongly visco-elastic at macro- and micro-length scales. The disintegration, drug release, and mechanical strength of OSD forms depend on its micro-texture (such as...