Peer-reviewed journal (1-2 of 2)

1. Investigation of Wet Milling and Indirect Ultrasound as Means for Controlling Nucleation in the Continuous Crystallization of an Active Pharmaceutical Ingredient

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   09 Jun 2023 | Contributor(s):: Yang, YH, Ahmed, BMitchell, C, Quon, JL, Siddique, H, Houson, I, Florence, AJ, Papageorgiou, CD

   This study compares the use of wet milling and indirect ultrasound for promoting nucleation and controlling the particle size during the continuous crystallization of a hard-to-nucleate active pharmaceutical ingredient (API). Both an immersion and an external wet mill installed on a recirculation...

2. Advanced methodologies for cocrystal synthesis

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   09 Jun 2023 | Contributor(s):: Douroumis, D, Ross, SA, Nokhodchi, A

   Pharmaceutical cocrystals are multicomponent systems composed of two or more molecules and held together by H-bonding. Currently, cocrystals provide exciting opportunities in the pharmaceutical industry for the development and manufacturing of new medicines by improving poor physical properties...