A scaled down method for identifying the optimum range of L/S ratio in twin screw wet granulation using a regime map approach
Contributor(s):: Pradhan, Shankali U., Bullard, Joseph W., Dale, Steven, Ojakovo, Peter, Bonnassieux, Alexandre
Twin screw wet granulation (TSWG) has gained momentum in the pharmaceutical industry for effective continuous granulation of solid dosage products. Liquid-to-solid (L/S) ratio is a key process parameter affecting granule properties. Identifying an optimum range of L/S ratio while reducing the...