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Tags: unstable intermediates

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  1. A Practical and Robust Multistep Continuous Process for Manufacturing 5-Bromo-N-(tert-butyl)pyridine-3-sulfonamide

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    09 Jun 2023 | Contributor(s):: Yu, M, Strotman, NASavage, SA, Leung, S, Ramirez, A

    A multistep continuous flow process involving (1) magnesium-halogen exchange, (2) sulfonylation with sulfuryl chloride, and (3) reaction with tert-butylamine was developed for the synthesis of an arylsulfonamide pharmaceutical intermediate in the synthesis of BMS-919373. The process was...