Methodology for a Variable Rate Control Strategy Development in Continuous Manufacturing Applied to Twin-screw Wet-Granulation and Continuous Fluid-bed Drying
Contributor(s):: Pauli, Victoria, Elbaz, Frantz, Kleinebudde, Peter, Krumme, Markus
Purpose: Continuous manufacturing (CM) promises unrestricted scale up of production volume through runtime, together with lower product quality variability through stricter process control. However, unforeseen incidents that disrupt the process’ steady state or even force temporary shutdown of...