Investigation of Wet Milling and Indirect Ultrasound as Means for Controlling Nucleation in the Continuous Crystallization of an Active Pharmaceutical Ingredient
Contributor(s):: Yang, YH, Ahmed, BMitchell, C, Quon, JL, Siddique, H, Houson, I, Florence, AJ, Papageorgiou, CD
This study compares the use of wet milling and indirect ultrasound for promoting nucleation and controlling the particle size during the continuous crystallization of a hard-to-nucleate active pharmaceutical ingredient (API). Both an immersion and an external wet mill installed on a recirculation...
Engineering of acetaminophen particle attributes using a wet milling crystallisation platform
Contributor(s):: Ahmed, B, Brown, CJMcGlone, T, Bowering, DL, Sefcik, J, Florence, AJ
Wet milling coupled with crystallisation has considerable potential to deliver enhanced control over particle attributes. The effect of process conditions and wet mill configuration on particle size, shape and surface energy has been investigated on acetaminophen using a seeded cooling...