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What's New: Past Month

Knowledge Base feed

  1. Where do I go for documentation?

    Documentation can be found in HUBzero's documentation page.

    https://cmkc.usp.org/kb/misc/testarticle

  2. What are groups?

    Work together with your colleaguesCreate a group to organize your interactions. Group members can:Post content that only other group members are allowed to seeExport their content to other web...

    https://cmkc.usp.org/kb/groups/general

  3. Frequently Asked Questions

    What are tags? How do I create a new tag? How can I delete a tag? How can I remove a tag from a resource/group/my profile/etc? Is there a limit on the number of tags I can add to an item? Can I...

    https://cmkc.usp.org/kb/tags/faq

  4. Frequently Asked Questions

    What are resources?How do I upload a new resource?How can I delete a resource?Is there a limit on the number of resources I can submit?What are resources?Think of a hub as an empty library....

    https://cmkc.usp.org/kb/resources/faq

  5. Customize your dashboard page

    To change your dashboard page, simply click the Personalize button located in the upper-right corner of that page. The page will enter a customization mode where you may move modules around by...

    https://cmkc.usp.org/kb/tips/personalize

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Resources feed

  1. Process Development for Synthesizing the Cephalosporin Antibiotic Cefotaxime in Batch and Flow Mode

    Contributor(s):: Pieper, Matthias, Kumpert, Mario, König, Burghard, Schleich, Herbert, Bayer, Thomas, Gröger, Harald

    The pharmaceutically active substance cefotaxime, a commercial cephalosporin-type antibiotic, is accessible in an amide-bond-forming reaction from 7-aminocephalosporanic acid as the amine donor and nonactivated (Z)-(2-aminothiazol-4-yl)-methoxyiminoacetic acid as the acid component with...

  2. Rapid production of the anaesthetic mepivacaine through continuous, portable technology

    Contributor(s):: Díaz-Kruik, Pablo, Paradisi, Francesca

    Local anaesthetics such as mepivacaine are key molecules in the medical sector, so ensuring their supply chain is crucial for every health care system. Rapid production of mepivacaine from readily available commercial reagents and (non-dry) solvents under safe conditions using portable,...

  3. Scalable and Sustainable Synthesis of Calcium Dobesilate via Integrated Five-Step Continuous-Flow Chemistry

    Contributor(s):: Liu, Minjie, Wan, Li, Gao, Liang, Cheng, Dang, Jiang, Meifen, Chen, Fen-Er

    Calcium dobesilate is a widely prescribed veno-tonic drug in over 60 countries for treating chronic venous disease, diabetic retinopathy, and hemorrhoidal attack symptoms. Although two batchwise manufacturing routes to this treatment have been developed, the drawbacks, such as poor...

  4. Seven-Step Continuous Flow Synthesis of Linezolid Without Intermediate Purification

    Contributor(s):: Russel, M. Grace, Jamison, Timothy F.

    Herein, the blockbuster antibacterial drug linezolid is synthesized from simple starting blocks by a convergent continuous flow sequence involving seven (7) chemical transformations. This is the highest total number of distinct reaction steps ever performed in continuous flow without conducting...

  5. Synthesis of (±)-Pregabalin by Utilizing a Three-Step Sequential-Flow System with Heterogeneous Catalysts

    Contributor(s):: Ishitani, Haruro, Kanai, Kan, Saito, Yuki, Tsubogo, Tetsu, Kobayashi, Shū

    (±)-Pregabalin, a γ-amino acid derivative, has been synthesized by utilizing flow methods. A three-step sequential-flow reaction starting from commercial isovaleraldehyde and methyl malonate proceeded smoothly with heterogeneous catalysts to afford the precursor of pregabalin in yields of 75–100...

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Wiki Pages feed

  1. Main Page

    What are wiki pages? Wiki pages are user-written articles on a range of subjects. Any contributor or a group of contributors can create (and own) new articles, and there can be multiple articles...

    https://cmkc.usp.org/groups/edu/wiki/MainPage

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