A new approach is proposed to support prediction of tablet tensile strength as a function of both solid fraction (and/or compression pressure) and extent of lubrication by using empirical data to parameterise the model. This is a pre-requisite for simulation of the compaction unit operation where a linkage from tablet press operating parameters and formulation material properties to output tensile strength is required. The approach extends the previously published Kushner and Moore model to allow calculation across a range of solid fractions. The applicability of the approach is supported by testing using formulations with different commonly used pharmaceutical excipients.

• GlaxoSmithKline (GSK)

• Oral solid dose

1. Compression pressure
2. continuous manufacturing
3. In-silico
4. Lubrication
5. oral solid dose
6. Research Article
7. Scale-up
8. Tensile strength