-
Advancing tablet lubrication: A systematic comparison of feed frame lubrication and internal lubrication
| Contributor(s):: Jens Bartsch, Markus Thommes, Christopher Mathias, René Brands
For the continuous manufacturing of tablets, internal lubrication is often utilized. Here, lubricant is added to a pre-blend in an additional blending step. However, over-lubrication may occur, with a negative impact on the tablet quality. This study consequently focuses on the...
-
Lubricant Sensitivity of Direct Compression Grades of Lactose in Continuous and Batch Tableting Process
| Contributor(s):: Gerald A. Hebbink, Pauline H. M. Janssen, Jurjen H. Kok, Lorenzo Menarini, Federica Giatti, Caterina Funaro, Salvatore Fabrizio Consoli, Bastiaan H. J. Dickhoff
Modern pharmaceutical manufacturing based on Quality by Design and digitalisation is revolutionising the pharmaceutical industry. Continuous processes are promoted as they increase efficiency and improve quality control. Compared to batch blending, continuous blending is easier to scale and...
-
The effect of lubrication on density distributions of roller compacted ribbons
| Contributor(s):: Miguelez-Moran, A. M, Seville, J. P. K.
Roller compaction is a continuous dry granulation process for producing free flowing granules in order to increase the bulk density and uniformity of pharmaceutical formulations. It is a complicated process due to the diversity of powder blends and processing parameters involved. The properties...
-
Spectroscopic characterization of tablet properties in a continuous powder blending and tableting process
| Contributor(s):: Nagy, Brigitta, Farkas, Attila, Magyar, Krisztina, Démuth, Balázs, Marosi, György
By the advent of continuous pharmaceutical manufacturing, fast and accurate characterization of product quality has become of a major interest. Although it also promotes the real-time release testing approach, so far mainly content uniformity studies were performed by near-infrared (NIR)...
-
New approach to optimizing risk management of the sticking problem using scale-independent critical material attributes and the quantitative process parameter
| Contributor(s):: Ando, Hirotaka, Hara, Yuko, Sato, Kazunari, Dohi, Masafumi, Hakomori, Tadashi, Yonemochi, Etsuo
In pharmaceutical manufacturing of solid formulations, blending with a lubricant is a key process in preventing sticking during compression. Sticking not only results in tablets with a disfigured appearance but also brings about the interruption of continuous operations. The aim of our study was...
-
Lubricant based determination of design space for continuously manufactured high dose paracetamol tablets
| Contributor(s):: Taipale-Kovalainen, Krista, Karttunen, Anssi-Pekka, Ketolainen, Jarkko, Korhonen, Ossi
The objective of this study was to devise robust and stable continuous manufacturing process settings, by exploring the design space after an investigation of the lubrication-based parameters influencing the continuous direct compression tableting of high dose paracetamol tablets. Experimental...
-
Lubrication empirical model to predict tensile strength of directly compressed powder blends
| Contributor(s):: Nassar, Joelle, Williams, Ben, Davies, Conrad, Lief, Kevin, Elkes, Richard
A new approach is proposed to support prediction of tablet tensile strength as a function of both solid fraction (and/or compression pressure) and extent of lubrication by using empirical data to parameterise the model. This is a pre-requisite for simulation of the compaction unit operation where...
-
Impact of Vertical Blender Unit Parameters on Subsequent Process Parameters and Tablet Properties in a Continuous Direct Compression Line
| Contributor(s):: Kreiser, MJ, Wabel, C, Wagner, KG
The continuous manufacturing of solid oral-dosage forms represents an emerging technology among the pharmaceutical industry, where several process steps are combined in one production line. As all mixture components, including the lubricant (magnesium stearate), are passing simultaneously through...
-
Experimental investigation and modelling of tensile strength of pharmaceutical tablets based on shear force applied by feed frame paddles
| Contributor(s):: Furukawa, Ryoichi, Singh, Ravendra, Ierapetritou, Marianthi
The feed frame is an essential device used in a rotary tablet press and it improves the performance of the powder filling process into dies. However, the feed frame affects critical quality attributes such as a tensile strength and a dissolution negatively due to a shear applied to powders from...