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Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms

By Rogers, Amanda J; Hashemi, Amir; Ierapetritou, Marianthi

Published on

Abstract

The objective of this work is to present a review of computational tools and models for pharmaceutical processes, specifically those for the continuous manufacture of solid dosage forms. Relevant mathematical methods and simulation techniques are discussed, as is the development of process models for solids-handling unit operations. Continuous processing is of particular interest in the current study because it has the potential to improve the efficiency and robustness of pharmaceutical manufacturing processes.

Journal

Processes. Volume 1, 2013, 67-127

DOI

10.3390/pr1020067

Type of publication

Peer-reviewed journal

Affiliations

  • Budapest University of Technology and Economics

Article Classification

Review article

Classification Areas

  • PAT
  • Oral Solid dose CM
  • Modeling

Tags