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Starch Products as Candidate Excipients in a Continuous Direct Compression Line
Contributor(s):: Sonia M. Razavi, Yi Tao, James Scicolone, Tami Morker, Charles Cunningham, Ali Rajabi-Siahboomi, Douglas B. Hausner, Fernando J. Muzzio
Purpose Direct compression (DC) remains the most preferred technique to produce tablets, and its effectiveness is directly influenced by raw material attributes. Therefore, the selection of specific grades of excipients to achieve desirable powder flow and compression properties is of importance....
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Recent progress in continuous and semi-continuous processing of solid oral dosage forms: a review
Contributor(s):: Tezyk, Michal, Ernst, Andrzej, Milanowski, Bartlomiej, Lulek, Janina
Continuous processing is an innovative production concept well known and successfully used in other industries for many years. The modern pharmaceutical industry is facing the challenge of transition from a traditional manufacturing approach based on batch-wise production to a continuous...
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Powder technology in the pharmaceutical industry: the need to catch up fast
Contributor(s):: Fernando J. Muzzio, Troy Shinbrot, Benjamin JGlasser
Pharmaceutical product development and manufacturing, which is largely an exercise in particle technology, is in serious need of technical upgrading. In this article, an overview of the current state of the art is provided, along with a discussion of expected Research Article trends and their...
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Predicting feeder performance based on material flow properties
Contributor(s):: Yifan Wang, Benjamin J. Glasser, Fernando J. Muzzio
Purpose: Accurate and consistent delivery of materials by well-designed feeders ensures overall process stability. Importantly, feeding performance is strongly dependent on material flow properties. The purpose of this study is to develop a methodology that identifies predictive correlation...
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Perspectives on the continuous manufacturing of powder‐based pharmaceutical processes
Contributor(s):: Marianthi Ierapetritou, Fernando Muzzio, Gintaras Reklaitis
The Pharmaceutical industry is a global business sector with $1 trillion annual sales focused on performance based products designed to address the healthcare needs of the world's population. In the last decade, the industry has been experiencing a number of important changes in its business...
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Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms
Contributor(s):: Rogers, Amanda J, Hashemi, Amir, Ierapetritou, Marianthi
The objective of this work is to present a review of computational tools and models for pharmaceutical processes, specifically those for the continuous manufacture of solid dosage forms. Relevant mathematical methods and simulation techniques are discussed, as is the development of process models...
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Method for characterization of loss-in-weight feeder equipment
Contributor(s):: William E. Engisch, Fernando J. Muzzio
This paper presents a method for evaluating the steady state performance of loss-in-weight powder feeding equipment and then demonstrates the use of the method in evaluating the performance of a K-Tron KT35 loss-in-weight feeder for three pharmaceutical grade powders. The method describes in...
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Feedrate deviations caused by hopper refill of loss-in-weight feeders
Contributor(s):: William E. Engisch, Fernando J. Muzzio
Continuous powder processing requires accurate and consistent feed streams of the raw materials which makes loss-in-weight feeders invaluable. Periodic hopper refill of the feeders, which is needed for continuous operation, can lead to inconsistent and poor feeding performance. This paper...
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Development and applications of a material library for pharmaceutical continuous manufacturing of solid dosage forms
Contributor(s):: Yifan Wang, ThomasO'Connor, TianyiLi, Muhammad Ashraf
The purpose of this study is to establish a material library and discuss its potential application to the development and lifecycle management of a continuous manufacturing process for solid dosage forms. Particularly, this study addresses the importance of selecting process-relevant testing...
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Continuous manufacturing: the future in pharmaceutical solid dosage form manufacturing
Contributor(s):: Desai, Parind Mahendrakumar, Van Vaerenbergh, Griet, Holman, Jim, Liew, Celine Valeria, Heng, Paul Wan Sia
As rising costs outpace new drug development, the pharmaceutical industry has come under intense pressure to improve the efficiency of its manufacturing processes. Continuous process manufacturing provides a proven solution. Among its many benefits are: minimized waste, energy consumption, and...
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Continuous powder feeding for pharmaceutical solid dosage form manufacture: a short review
Contributor(s):: Blackshields, Caroline A., Crean, Abina M.
Offers an extremely well-informed look at the most promising future approaches to continuous manufacturing of innovative pharmaceutical products
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Continuous manufacturing process monitoring of pharmaceutical solid dosage form: A case study
Contributor(s):: Roggo, Yves, Pauli, Victoria, Jelsch, Morgane, Pellegatti, Laurent, Elbaz, Frantz, Ensslin, Simon, Kleinebudde, Peter, Krumme, Markus
The most prevalent pharmaceutical dosage forms at present are granular solids in the form of oral tablets and capsules. While effective in releasing drug rapidly upon contact with gastrointestinal fluid, their manufacture, which relies on particulate processing, is fraught with difficulties...
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Continuous manufacture of polymeric cellular dosage forms
Contributor(s):: Blaesi, Aron H, Saka, Nannaji
The most prevalent pharmaceutical dosage forms at present are granular solids in the form of oral tablets and capsules. While effective in releasing drug rapidly upon contact with gastrointestinal fluid, their manufacture, which relies on particulate processing, is fraught with difficulties...