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Multiobjective optimization of an unseeded batch cooling crystallizer for shape and size manipulation

By Acevedo, David; Tandy, Yanssen; Nagy, Zoltan K.

Published on CMKC

Abstract

The optimization of unseeded batch cooling crystallization systems is studied in a multiobjective framework. The length mean size and target aspect ratio (AR) of final crystals were considered as objectives, which give rise to a set of optimal solutions known as Pareto-optimal solutions. Two model compounds were considered: paracetamol and potassium dyhidrogen phosphate (KDP), nucleation and growth dominated systems, respectively. The optimization of KDP showed a dependence between the optimal profile and the target objectives weights. The optimal profile for paracetamol did not vary from a cubic cooling profile due to the low sensitivity of the AR to temperature changes. Furthermore, the longer batch time has a greater impact on the optimal AR that could be achieved due to the variation in supersaturation dependence. Moreover, it was shown that there is a relation between the classification of crystallization kinetics based on growth and nucleation mechanisms and the set of optimal cooling profiles for shape and size optimization.

Journal

Industrial & Engineering Chemistry Research. Volume 54, 7, 2015, 2156-2166

DOI

10.1021/acs.iecr.5b00173

Type of publication

Peer-reviewed journal

Affiliations

  • Purdue University, Department of Chemical Engineering

Article Classification

Research Article

Classification Areas

  • Control
  • Modeling

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