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Multiobjective optimization of an unseeded batch cooling crystallizer for shape and size manipulation
Contributor(s):: Acevedo, David, Tandy, Yanssen, Nagy, Zoltan K.
The optimization of unseeded batch cooling crystallization systems is studied in a multiobjective framework. The length mean size and target aspect ratio (AR) of final crystals were considered as objectives, which give rise to a set of optimal solutions known as Pareto-optimal solutions. Two...
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Continuous Crystallization of Aliskiren Hemifumarate
Contributor(s):: Quon, JL, Zhang, HAlvarez, A, Evans, J, Myerson, AS, Trout, BL
Active ingredients in most pharmaceutical products are complex organic molecules that require crystallization as a purification and isolation step that results in a pure product at a high process yield. Knowledge of the operating conditions required to obtain crystals with the desired crystal...
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Complexation-Assisted Continuous Crystallization of Isomeric Systems with Nanofiltration Recycle
Contributor(s):: Vartak, S, Myerson, AS
In API-impurity systems consisting of structural isomers, the impurity has a strong affinity to incorporate into the host crystal owing to their identical molecular weight and similar structure. Conventional successive recrystallization turns out to be an unattractive purification strategy in...
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Composite Hydrogels Laden with Crystalline Active Pharmaceutical Ingredients of Controlled Size and Loading
Contributor(s):: Eral, HB, O'Mahony, MShaw, R, Trout, BL, Myerson, AS, Doyle, PS
Efficient control of crystallization and crystal properties still represents a bottleneck in the manufacturing of crystalline materials ranging from pigments to semiconductor particles. In the case of pharmaceutical drug manufacture, current methods for controlling critical crystal properties...
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Application of process analytical technology-based feedback control for the crystallization of pharmaceuticals in porous media
Contributor(s):: Acevedo, David A., Ling, Jing Chadwick, Keith, Nagy, Zoltak K. ;
The purpose of this work is to implement a feedback control approach during the cooling crystallization of paracetamol (PCM) in porous media to increase the amount of PCM in the alginate beads (i.e., drug loading) and minimize the heterogeneous nucleation occurring in the bulk system. Two types...
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Analytical Design and Operation of Systems with Crystallization, Filtration, and Recycling
Contributor(s):: Ward, Jeffrey D, Yu, Cheng-ching, Doherty, Michael F
In this article, we introduce an analogous dimensionless model for a continuous rotary drum filter and show that a similar methodology can be used to predict the behavior of a combined crystallizer and filter, and a reactor, crystallizer, filter, and recycle circuit. We show the effect of the...
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A Stochastic Population Balance Equation Model for Nucleation and Growth of Crystals with Multiple Polymorphs
Contributor(s):: Maggioni, Giovanni, Mazzotti, Marco
Understanding polymorph crystallization is important due to the different properties, such as bioavailability or crystal shape, exhibited by the different crystal forms. In this work, we present a model, based on population balance equations, describing the unseeded crystallization by cooling of...
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A Process for the Formation of Nanocrystals of Active Pharmaceutical Ingredients with Poor Aqueous Solubility in a Nanoporous Substrate
Contributor(s):: O'Mahony, M, Leung, AKFerguson, S, Trout, BL, Myerson, AS
A potential process for the formation of nanocrystals of the poorly soluble drug, ibuprofen, within a nanoporous material is demonstrated. Nanocrystalline ibuprofen (IBP) is prepared at <= 106 nm by adding a solution containing IBP to particles of controlled pore glass (CPG) within a column so...