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Particle Engineering of an Active Pharmaceutical Ingredient for Improved Micromeritic Properties

By Sowa, M; Klapwijk, AROstendorf, M; Beckmann, W

Published on CMKC

Abstract

A range of particle-engineering techniques were applied to modify unfavorable bulk solid properties of an active pharmaceutical ingredient (API), with the solid-state form of the compound remaining constant. The compound under investigation has been crystallized as needle-like particles, which lead to poor powder-flow properties, ineffective processing, and problematic formulation behavior. The results show that design and optimization of a cooling crystallization procedure as well as application of alternative approaches, i.e., spherical agglomeration, additive-controlled crystallization, or ultrasonication, can improve the solid-state properties of the studied compound. The improvements were quantified by measuring bulk density and flowability, and by comparing the jet-milling behavior.

Journal

Chemical Engineering & Technology. Volume 40, 2017, 1282-1292

DOI

10.1002/ceat.201600663

Type of publication

Peer-reviewed journal

Affiliations

  • Bayer AG
  • University of Bath

Article Classification

Research Article

Classification Areas

  • API

Tags