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Progress of Pharmaceutical Continuous Crystallization

By Zhang, DJ; Xu, SJDu, SC; Wang, JK; Gong, JB

Published on

Abstract

Crystallization is an important unit operation in the pharmaceutical industry. At present, most pharmaceutical crystallization processes are performed in batches. However, due to product variability from batch to batch and to the low productivity of batch crystallization, continuous crystallization is gaining increasing attention. In the past few years, progress has been made to allow the products of continuous crystallization to meet different requirements. This review summarizes the progress in pharmaceutical continuous crystallization from a product engineering perspective. The advantages and disadvantages of different types of continuous crystallization are compared, with the main difference between the two main types of crystallizers being their difference in residence time distribution. Approaches that use continuous crystallization to meet different quality requirements are summarized. Continuous crystallization has advantages in terms of size and morphology control. However, it also has the problem of a process yield that may be lower than that of a batch process, especially in the production of chirality crystals. Finally, different control strategies are compared. (C) 2017 THE AUTHORS. Published by Elsevier LTD on behalf of the Chinese Academy of Engineering and Higher Education Press Limited Company.

Journal

Engineering. Volume 3, 2017, 354-364

DOI

10.1016/ENG.2017.03.023

Type of publication

Peer-reviewed journal

Affiliations

  • Tianjin University

Article Classification

Review article

Classification Areas

  • API
  • Modeling
  • PAT

Tags