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Recent Progress in Continuous Crystallization of Pharmaceutical Products: Precise Preparation and Control
Contributor(s):: Ma, Yiming, Joao Macaringue, Estevao, Zhang, Teng, Gong, Junbo, Wu, Songgu, Wang, Jingkang
Crystallization, as a solid−liquid separation process, is employed to purify and isolate a great diversity of crystalline pharmaceutical products. In recent years, continuous crystallization has attracted increasing attention because of the product and process robustness as well as higher...
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Progress of Pharmaceutical Continuous Crystallization
Contributor(s):: Zhang, DJ, Xu, SJDu, SC, Wang, JK, Gong, JB
Crystallization is an important unit operation in the pharmaceutical industry. At present, most pharmaceutical crystallization processes are performed in batches. However, due to product variability from batch to batch and to the low productivity of batch crystallization, continuous...
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Mathematical Modeling, Design, and Optimization of a Multisegment Multiaddition Plug-Flow Crystallizer for Antisolvent Crystallizations
Contributor(s):: Su, Qinglin, Benyahia, Brahim Nagy, Zoltan K., Rielly, Chris D.
In the pharmaceutical industries, the requirements of rapid process development and scalable design have made the tubular crystallizer a promising platform for continuous manufacturing and crystallization processes, capable of replacing conventional capital- and labor-intensive batch operations....