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Recent Progress in Continuous Crystallization of Pharmaceutical Products: Precise Preparation and Control

By Ma, Yiming; Joao Macaringue, Estevao; Zhang, Teng; Gong, Junbo; Wu, Songgu; Wang, Jingkang

Published on

Abstract

Crystallization, as a solid−liquid separation process, is employed to purify and isolate a great diversity of crystalline pharmaceutical products. In recent years, continuous crystallization has attracted increasing attention because of the product and process robustness as well as higher productivity. In this work, we review the use of novel continuous crystallizers or modified conventional continuous crystallizers for the preparation of polymorphs, chiral enantiomers, solvates/hydrates, cocrystals, and spherical crystals. In addition, the theoretical framework and verification of the model-based control approaches are demonstrated. The application of process analytical technology tools in classical feedback loop control strategies in continuous crystallization is also discussed. Despite all this, the application of continuous crystallization still remains challenging because of the existence of drawbacks such as fouling and blockages. Therefore, a systematic discussion should be done before continuous crystallization is morewidely applied

Journal

Organic Process Research & Development. Volume 24, 2020, 1785-1801

DOI

10.1021/acs.oprd.9b00362

Type of publication

Peer-reviewed journal

Affiliations

  • Tianjin University

Article Classification

Review article

Classification Areas

  • PAT
  • API

Tags