Progress to Date in the Design and Operation of Continuous Crystallization Processes for Pharmaceutical Applications
Category
Published on CMKC
Abstract
Continuous crystallization has gained interest in the pharmaceutical sector as part of the drive toward thetransition from exclusive batch manufacturing to integrated continuous manufacturing in this industry. As a result, the design and operation of continuous crystallization processes for the preparation of pharmaceutical materials has been featured strongly in recent scientific literature. This review is an effort to gather together all of the published understanding on continuous crystallization with a pharmaceutical focus and to benchmark progress to date in realizing the potential benefits of transitioning this stalwart pharmaceutical unit operation from batch to continuous configurations.
Journal
Organic Process Research & Development. Volume 23, 2019, 122-144
DOI
10.1021/acs.oprd.8b00319
Type of publication
Peer-reviewed journal
Affiliations
- University of Limerick
- Pfizer Inc.
- Eli Lilly and Company
Article Classification
Review article
Classification Areas
- PAT
- API