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18.226.17.210

Progress to Date in the Design and Operation of Continuous Crystallization Processes for Pharmaceutical Applications

By Wood, Barbara; Girard, Kevin; Polster, Christopher; Croker, Denise

View Resource (DOI)

Category

Peer-reviewed journal

Published on

Abstract

Continuous crystallization has gained interest in the pharmaceutical sector as part of the drive toward thetransition from exclusive batch manufacturing to integrated continuous manufacturing in this industry. As a result, the design and operation of continuous crystallization processes for the preparation of pharmaceutical materials has been featured strongly in recent scientific literature. This review is an effort to gather together all of the published understanding on continuous crystallization with a pharmaceutical focus and to benchmark progress to date in realizing the potential benefits of transitioning this stalwart pharmaceutical unit operation from batch to continuous configurations.

Journal

Organic Process Research & Development. Volume 23, 2019, 122-144

DOI

10.1021/acs.oprd.8b00319

Type of publication

Peer-reviewed journal

Affiliations

  • University of Limerick
  • Pfizer Inc.
  • Eli Lilly and Company

Article Classification

Review article

Classification Areas

  • PAT
  • API

Tags

  1. API
  2. COBC
  3. Continuous crystallization
  4. MSMPR crystallization
  5. pat
  6. Pharmaceutical Manufacturing
  7. Plug flow crystallizers
  8. Review article