Template-induced nucleation for controlling crystal polymorphism: from molecular mechanisms to applications in pharmaceutical processing
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Published on CMKC
Abstract
Over the last two decades, the use of template surfaces to induce heterogeneous crystal nucleation has been explored primarily to address two different goals: first, as an alternative to the conventional seeding technique used for polymorph control and, second, as a technique to promote the nucleation rate in novel crystallisation processes and formulations. The former need conceivably arises due to the risk of crystallising a new polymorph despite pre-seeding the solution with the desired crystal form. In this context, we review ongoing efforts in the Research Article area of template-induced crystallisation, covering both experimental and simulation studies directed towards deeper understanding of the underpinning mechanisms. In addition, we report on the use of template-induced crystal nucleation as a process intensification technology for formulating drug substances and as a technique for enabling nucleation and polymorphic control during continuous manufacturing of active pharmaceutical ingredients.
Journal
DOI
Type of publication
Affiliations
- Indian Institute of Technology Patna
- ASTAR (Agency for Science, Technology and Research, Singapore)
- National University of Singapore; Imperial College London
Article Classification
Classification Areas
- API