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Template-induced nucleation for controlling crystal polymorphism: from molecular mechanisms to applications in pharmaceutical processing

By Parambil, JV; Poornachary, SKHeng, JYY; Tan, RBH

Published on CMKC

Abstract

Over the last two decades, the use of template surfaces to induce heterogeneous crystal nucleation has been explored primarily to address two different goals: first, as an alternative to the conventional seeding technique used for polymorph control and, second, as a technique to promote the nucleation rate in novel crystallisation processes and formulations. The former need conceivably arises due to the risk of crystallising a new polymorph despite pre-seeding the solution with the desired crystal form. In this context, we review ongoing efforts in the Research Article area of template-induced crystallisation, covering both experimental and simulation studies directed towards deeper understanding of the underpinning mechanisms. In addition, we report on the use of template-induced crystal nucleation as a process intensification technology for formulating drug substances and as a technique for enabling nucleation and polymorphic control during continuous manufacturing of active pharmaceutical ingredients.

Journal

CrystEngComm. Volume 21, 2019, 4122-4135

DOI

10.1039/c9ce00404a

Type of publication

Peer-reviewed journal

Affiliations

  • Indian Institute of Technology Patna
  • ASTAR (Agency for Science, Technology and Research, Singapore)
  • National University of Singapore; Imperial College London

Article Classification

Review article

Classification Areas

  • API

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