Template-induced nucleation for controlling crystal polymorphism: from molecular mechanisms to applications in pharmaceutical processing
Contributor(s):: Parambil, JV, Poornachary, SKHeng, JYY, Tan, RBH
Over the last two decades, the use of template surfaces to induce heterogeneous crystal nucleation has been explored primarily to address two different goals: first, as an alternative to the conventional seeding technique used for polymorph control and, second, as a technique to promote the...
Formation of organic molecular nanocrystals under soft confinement
Contributor(s):: Yang, XC, Ong, TCMichaelis, VK, Heng, S, Griffin, RG, Myerson, AS
Methods to produce nano-sized organic molecular crystals in thin films are of great interest in the pharmaceutical industry due to the potential benefit of increased solubility of poorly soluble drugs and the advantages of film-based dosage forms over traditional tablet/capsule-based dosage...