The objective of this study was to develop a novel closed-loop controlled continuous tablet manufacturing line, which first uses hot melt extrusion (HME) to produce pellets based on API and a polymer matrix. Such systems can be used to make complex pharmaceutical formulations, e.g., amorphous solid dispersions of poorly soluble APIs. The pellets are then fed to a direct compaction (DC) line blended with an external phase and tableted continuously. Fully-automated processing requires advanced control strategies, e.g., for reacting to raw material variations and process events. While many tools have been proposed for in-line process monitoring and real-time data acquisition, establishing real-time automated feedback control based on in-process control strategies remains a challenge. Control loops were implemented to assess the quality attributes of intermediates and product and to coordinate the mass flow rate between the unit operations. Feedback control for the blend concentration, strand temperature and pellet thickness was accomplished via proportional integral derivative (PID) controllers. The tablet press hopper level was controlled using a model predictive controller. To control the mass flow rates in all unit operations, several concepts were developed, with the tablet press, the extruder or assigned to be the master unit of the line, and compared via the simulation.

• Research Article Center Pharmaceutical Engineering GmbH
• Graz University of Technology
• Evon GmbH / Merck KG & Co Werk Spittal

• PAT
• Oral solid dose
• Control

1. Advanced process control
2. continuous manufacturing
3. Control
4. Direct compaction
5. hot-melt extrusion
6. Model predictive control
7. oral solid dose
8. pat
9. Pat strategy / Control concept
10. Research Article