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Twin Screw Granulation: Effects of Properties of Primary Powders

By Lute, Sushma, V; Dhenge, Ranjit M.; Salman, Agba D.

Published on CMKC

Abstract

Lactose and mannitol are some of the most commonly used powders in the pharmaceutical industry. The limited Research Article published so far highlights the effects of process and formulation parameters on the properties of the granules and the tablets produced using these two types of powders separately. However, the comparison of the performance of these two types of powders during twin screw wet granulation has received no attention. The present Research Article is focused on understanding the granulation mechanism of different grades of two pharmaceutical powders with varying properties (i.e., primary particle size, structure, and compressibility). Three grades each of lactose and mannitol were granulated at varying liquid to solid ratios (L/S) and screw speed. It was noticed that primary powder morphology plays an important role in determining the granule size and structure, and tablet tensile strength. It was indicated that the processed powders such as spray-dried and granulated lactose and mannitol can be used in formulation for wet granulation where flowability of active pharmaceutical ingredient (API) is poor.

Journal

Pharmaceutics. Volume 10, 2, 2018, 68

DOI

10.3390/pharmaceutics10020068

Type of publication

Peer-reviewed journal

Affiliations

  • University of Sheffield

Article Classification

Research article

Classification Areas

  • Oral solid dose

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