Skip to main content
18.97.14.83

Videometric mass flow control: A new method for real-time measurement and feedback control of powder micro-feeding based on image analysis

By Madarasz, L; Kote, AGyurkes, M; Farkas, A; Hambalko, B; Pataki, H; Fulop, G; Marosi, G; Lengyel, L; Casian, T; Csorba, K; Nagy, ZK

Published on

Abstract

The present paper reports the first monitoring and control of ultra-low dose powder feeding using a camera image-based mass flow measurement system. Caffeine was fed via a single-screw microfeeder as a model active pharmaceutical ingredient (API). The mass, mass flow and sizes of the particles were successfully monitored in real-time by the developed videometric system consisting of a high-speed process camera coupled with an image analysis software. The system was also tested in feedback control mode to automatically reach the desired mass flow values by adjusting the feeder speed based on the mass flow measured by the image analysis system. Based on these features, the developed videometric system can serve as a multi-purpose PAT-tool and can provide valuable real-time information about the process which is indispensable for modern continuous pharmaceutical manufacturing.

Journal

International Journal of Pharmaceutics. Volume 580, 2020, 119223

DOI

10.1016/j.ijpharm.2020.119223

Type of publication

Peer-reviewed journal

Affiliations

  • Budapest University of Technology and Economics
  • Iuliu Hatieganu University of Medicine and Pharmacy

Article Classification

Research Article

Classification Areas

  • API
  • Process control

Tags