Described is a continuous, divergent synthesis system which is coupled to continuous purification and is capable of producing four anti-malarial APIs. The system is comprised of three linked reaction modules for photooxidation/cyclization, reduction, and derivatization. A fourth module couples the crude reaction stream with continuous purification to yield pure API.

• Max-Planck
• Otto-von-Guericke-University
• Freie Universität Berlin

• API

1. antimalarial
2. API
3. Artemisinin
4. derivatization
5. divergent synthesis system
6. photooxidation/cyclization
7. reduction
8. Research Article