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Continuous synthesis of artemisinin-derived medicines

By Gilmore, Kerry; Kopetzki, Daniel; Lee, Ju Weon; Horváth, Zoltán; McQuade, D. Tyler; Seidel-Morgenstern, Andreas; Seeberger, Peter H.

Published on

Abstract

Described is a continuous, divergent synthesis system which is coupled to continuous purification and is capable of producing four anti-malarial APIs. The system is comprised of three linked reaction modules for photooxidation/cyclization, reduction, and derivatization. A fourth module couples the crude reaction stream with continuous purification to yield pure API.

Journal

Chemical Communications. Volume 50, 2014, 12652-12655

DOI

10.1039/C4CC05098C

Type of publication

Peer-reviewed journal

Affiliations

  • Max-Planck
  • Otto-von-Guericke-University
  • Freie Universität Berlin

Article Classification

Research article

Classification Areas

  • API

Tags