Continuous synthesis of artemisinin-derived medicines
Category
Published on CMKC
Abstract
Described is a continuous, divergent synthesis system which is coupled to continuous purification and is capable of producing four anti-malarial APIs. The system is comprised of three linked reaction modules for photooxidation/cyclization, reduction, and derivatization. A fourth module couples the crude reaction stream with continuous purification to yield pure API.
Journal
Chemical Communications. Volume 50, 2014, 12652-12655
DOI
10.1039/C4CC05098C
Type of publication
Peer-reviewed journal
Affiliations
- Max-Planck
- Otto-von-Guericke-University
- Freie Universität Berlin
Article Classification
Research article
Classification Areas
- API