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3.144.2.29

Continuous-flow synthesis of the anti-malaria drug artemisinin

By Lévesque, François; Seeberger, Peter H

Published on CMKC

Abstract

Malaria is a serious global health issue. Artemisinin combination treatments are the first-line drugs, but supplies are limited because artemisinin is obtained solely by extraction from Artemisia annua. A continuous-flow process that converts dihydroartemisinic acid into artemisinin (see scheme) was shown to be an inexpensive and scalable process that can ensure a steady, affordable supply of artemisinin.

Journal

Angewandte Chemie International Edition. Volume 51, 2012, 1706-1709

DOI

10.1002/anie.201107446

Type of publication

Peer-reviewed journal

Affiliations

  • Max-Planck Society

Article Classification

Research Article

Classification Areas

  • API

Tags