Integrated continuous manufacturing has emerged as a promising device for the rapid manufacturing of active pharmaceutical ingredients (APIs). We herein report a newly designed continuous flow micro-total process system platform for the rapid manufacturing of celecoxib, a selective nonsteroidal anti-inflammatory drug. This approach has been proven generally for the synthesis of several alkyl and aryl substituted pyrazoles. In order to minimize the tedious work-up process of potential reaction intermediates/products, we have developed a continuous flow extraction and separation platform to carry out the entire reaction sequence resulting in a short residence time with good yield. The present process was further extended to gram scale synthesis of the COX-2-related API, viz. celecoxib, in the continuous flow process.

• Indian Institute of Chemical Technology
• Academy of Scientific and Innovative Research (AcSIR)

• API

1. API
2. COX-2 inhibitor
3. in-line IR
4. integrated continuous flow
5. pyrazoles API
6. Research Article
7. ultrafast synthesis