A multi-step process using continuous flow chemistry to produce propofol is described. A scale-up of a 5-stage process (two continuous flow chemical steps, two extractions using a semi-batch approach, and one purification) provided propofol in high purity. This process minimizes the number of impurities formed during the double Friedel–Crafts reaction allowing to run two continuous flow chemical steps sequentially. The use of simple, inexpensive, and readily available reagents affords a viable process for this widely employed active pharmaceutical ingredient.

• Université de Montréal

• API

1. API
2. continuous flow synthesis
3. decarboxylation
4.  Friedel–Crafts reaction
5.  propofol 
6. Research Article
7. Scale-up