Process Intensive Synthesis of Propofol Enabled by Continuous Flow Chemistry
Category
Published on
Abstract
A multi-step process using continuous flow chemistry to produce propofol is described. A scale-up of a 5-stage process (two continuous flow chemical steps, two extractions using a semi-batch approach, and one purification) provided propofol in high purity. This process minimizes the number of impurities formed during the double Friedel–Crafts reaction allowing to run two continuous flow chemical steps sequentially. The use of simple, inexpensive, and readily available reagents affords a viable process for this widely employed active pharmaceutical ingredient.
Journal
Organic Process Research & Development. Volume 26, 2022, 2330–2336
DOI
10.1021/acs.oprd.1c00416
Type of publication
Peer-reviewed journal
Affiliations
- Université de Montréal
Article Classification
Research Article
Classification Areas
- API