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Process Intensive Synthesis of Propofol Enabled by Continuous Flow Chemistry

By Vinet, Laurent; Di Marco, Lorenzo; Kairouz, Vanessa; Charette, André B.

Published on

Abstract

A multi-step process using continuous flow chemistry to produce propofol is described. A scale-up of a 5-stage process (two continuous flow chemical steps, two extractions using a semi-batch approach, and one purification) provided propofol in high purity. This process minimizes the number of impurities formed during the double Friedel–Crafts reaction allowing to run two continuous flow chemical steps sequentially. The use of simple, inexpensive, and readily available reagents affords a viable process for this widely employed active pharmaceutical ingredient.

Journal

Organic Process Research & Development. Volume 26, 2022, 2330–2336

DOI

10.1021/acs.oprd.1c00416

Type of publication

Peer-reviewed journal

Affiliations

  • Université de Montréal

Article Classification

Research Article

Classification Areas

  • API

Tags