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Advancing Flow Chemistry Portability: A Simplified Approach to Scaling Up Flow Chemistry

By Lévesque, François; Rogus, Nicholas J.; Spencer, Glenn; Grigorov, Plamen; McMullen, Jonathan P.; Thaisrivongs, David A.; Davies, Ian W.; Naber, John R.

View Resource (DOI)

Category

Peer-reviewed journal

Published on CMKC

Abstract

We report mixing characterization of five lab-scale and eight production-scale static mixers using a modified fourth Bourne reaction. An efficient inline method relying on UV–vis spectroscopy was developed to streamline analysis of the product distribution. As a result of these studies, we have designed, 3D-printed, and characterized a stainless steel static mixer. This approach enabled the evaluation of different configurations and ensured efficient scale-up across development and commercial facilities that should allow for enhanced portability of mixing-sensitive processes.

Journal

Organic Process Research & Development. Volume 22, 2018, 1015–1021

DOI

10.1021/acs.oprd.8b00063

Type of publication

Peer-reviewed journal

Affiliations

  • Merck & Co., Inc.

Article Classification

Research Article

Classification Areas

  • Intermediate

Tags

  1. Bourne reaction
  2. in-line analysis
  3. Intermediate
  4. Research Article
  5. Scale-up
  6. static mixer
  7. UV/Vis spectroscopy