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1. Advancing Flow Chemistry Portability: A Simplified Approach to Scaling Up Flow Chemistry

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   Contributor(s):: Lévesque, François, Rogus, Nicholas J., Spencer, Glenn, Grigorov, Plamen, McMullen, Jonathan P., Thaisrivongs, David A., Davies, Ian W., Naber, John R.

   We report mixing characterization of five lab-scale and eight production-scale static mixers using a modified fourth Bourne reaction. An efficient inline method relying on UV–vis spectroscopy was developed to streamline analysis of the product distribution. As a result of these studies, we have...

2. The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

   out of 5 stars 

   Contributor(s):: Baumann, M, Baxendale, IR

   The implementation of continuous flow processing as a key enabling technology has transformed the way we conduct chemistry and has expanded our synthetic capabilities. As a result many new preparative routes have been designed towards commercially relevant drug compounds achieving more efficient...