Continuous Flow Synthesis of 16-Dehydropregnenolone Acetate, a Key Synthon for Natural Steroids and Drugs
Category
Published on
Abstract
A telescoped multistep process to provide the continuous delivery of 16-dehydropregnenolone acetate (16-DPA) from diosgenin is described. The method was evaluated through batch screenings that helped to identify critical bottlenecks and flowability, and the best conditions were optimized in flow systems before the individual steps were telescoped together into a single integrated flow process. Further highlights of our approach include the use of efficient in-line extraction operations and reaction monitoring, the avoidance of time-consuming purifications between steps, and improvement of efficiency and safety standards.
Journal
Organic Process Research & Development. Volume 22, 2018, 600-607
DOI
10.1021/acs.oprd.8b00038
Type of publication
Peer-reviewed journal
Affiliations
- University of Perugia
Article Classification
Research Article
Classification Areas
- Intermediate