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Development of a Large-Scale Cyanation Process Using Continuous Flow Chemistry En Route to the Synthesis of Remdesivir

By Vieira, Tiago; Stevens, Andrew C.; Chtchemelinine, Andrei; Gao, Detian; Badalov, Pavel; Heumann, Lars

Published on CMKC

Abstract

The implementation of cyanation chemistry at manufacturing scales using batch equipment can be challenging because of the hazardous nature of the reagents employed and the tight control of reaction parameters, including cryogenic temperatures, that help to afford acceptable selectivity and conversion for the desired reaction. Application of continuous flow chemistry offers a means to mitigate the risk associated with handling large amounts of hazardous reagents and to better control the reaction parameters. A case study describing the cyanation of a glycoside using continuous flow chemistry toward the synthesis of the drug candidate remdesivir is presented.

Journal

Organic Process Research & Development. Volume 24, 2020, 2113–2121

DOI

10.1021/acs.oprd.0c00172

Type of publication

Peer-reviewed journal

Affiliations

  • Gilead Alberta ULC
  • Gilead Sciences, Inc.

Article Classification

Research Article

Classification Areas

  • Intermediate

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