Development of a Large-Scale Cyanation Process Using Continuous Flow Chemistry En Route to the Synthesis of Remdesivir
Category
Published on CMKC
Abstract
The implementation of cyanation chemistry at manufacturing scales using batch equipment can be challenging because of the hazardous nature of the reagents employed and the tight control of reaction parameters, including cryogenic temperatures, that help to afford acceptable selectivity and conversion for the desired reaction. Application of continuous flow chemistry offers a means to mitigate the risk associated with handling large amounts of hazardous reagents and to better control the reaction parameters. A case study describing the cyanation of a glycoside using continuous flow chemistry toward the synthesis of the drug candidate remdesivir is presented.
Journal
Organic Process Research & Development. Volume 24, 2020, 2113–2121
DOI
10.1021/acs.oprd.0c00172
Type of publication
Peer-reviewed journal
Affiliations
- Gilead Alberta ULC
- Gilead Sciences, Inc.
Article Classification
Research Article
Classification Areas
- Intermediate