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Catalytic Static Mixers for the Continuous Flow Hydrogenation of a Key Intermediate of Linezolid (Zyvox)

By Gardiner, James; Nguyen, Xuan; Genet, Charlotte; Horne, Mike D.; Hornung, Christian H.; Tsanaktsidis, John

View Resource (DOI)

Category

Peer-reviewed journal

Published on CMKC

Abstract

Catalytic static mixers (CSMs) were used for the efficient preparation of a key intermediate of the antimicrobial drug linezolid (Zyvox). The approach combines 3D printing and additive manufacturing techniques with continuous flow processing to produce a general method for catalytic hydrogenations and the rapid production of the target molecule without the need for catalyst removal or recovery.

Journal

Organic Process Research & Development. Volume 22, 2018, 1448–1452

DOI

10.1021/acs.oprd.8b00153

Type of publication

Peer-reviewed journal

Affiliations

  • CSIRO Manufacturing
  • CSIRO Mineral Resources

Article Classification

Research Article

Classification Areas

  • Intermediate

Tags

  1. antimicrobial
  2. Catalytic static mixers (CSMs)
  3. hydrogenation
  4. Intermediate
  5. linezolid
  6. Research Article