Process Development for Synthesizing the Cephalosporin Antibiotic Cefotaxime in Batch and Flow Mode
Contributor(s):: Pieper, Matthias, Kumpert, Mario, König, Burghard, Schleich, Herbert, Bayer, Thomas, Gröger, Harald
The pharmaceutically active substance cefotaxime, a commercial cephalosporin-type antibiotic, is accessible in an amide-bond-forming reaction from 7-aminocephalosporanic acid as the amine donor and nonactivated (Z)-(2-aminothiazol-4-yl)-methoxyiminoacetic acid as the acid component with...