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1. Catalytic Static Mixers for the Continuous Flow Hydrogenation of a Key Intermediate of Linezolid (Zyvox)

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   25 Jun 2024 | Contributor(s):: Gardiner, James, Nguyen, Xuan, Genet, Charlotte, Horne, Mike D., Hornung, Christian H., Tsanaktsidis, John

   Catalytic static mixers (CSMs) were used for the efficient preparation of a key intermediate of the antimicrobial drug linezolid (Zyvox). The approach combines 3D printing and additive manufacturing techniques with continuous flow processing to produce a general method for catalytic...

2. Process Development for Synthesizing the Cephalosporin Antibiotic Cefotaxime in Batch and Flow Mode

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   24 Apr 2024 | Contributor(s):: Pieper, Matthias, Kumpert, Mario, König, Burghard, Schleich, Herbert, Bayer, Thomas, Gröger, Harald

   The pharmaceutically active substance cefotaxime, a commercial cephalosporin-type antibiotic, is accessible in an amide-bond-forming reaction from 7-aminocephalosporanic acid as the amine donor and nonactivated (Z)-(2-aminothiazol-4-yl)-methoxyiminoacetic acid as the acid component with...