Continuous manufacturing has intrigued many researchers in the pharmaceutical industry in the post-COVID-19 world. We experimentally studied the discharge characteristics of pharmaceutical excipients under vibrational excitation. The successful accurate dosing and filling of powders at fill rates of 0.6–15 mg/s was developed. A simple particle model includes fluid-grain coupling which is relevant to Faraday tilting resulting from gas trapped in the powder bed accurately predicts the discharge rate. A novel continuous micro mixing system was designed based on the discharge model. Any specified proportions can be realized by setting appropriate vibration parameters. The low variability (<2.5 %) in the content of components has verified the reliability of the mixing system. The continuous mixing performance was determined by the discharge characteristics. Yet the particle size distribution and cohesion lead to different mixing performances when the stability of micro feeding is satisfied. Reasonable process parameters for continuous mixing are determined and optimized.

• National Energy Coal Gasification Technology Research and Development Center, State Key Laboratory of Coal Liquification, Gasification and Utilization with High Efficiency and Low Carbon Technology, East China University of Science and Technology

• Oral Solid Dosage 
• API

1. API
2. Cohesive material
3. Continuous mixing
4. hopper discharge
5. localized vibratio
6. oral solid dose