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Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review

By Simon, Levente L; Pataki, Hajnalka; Marosi, György; Meemken, Fabian; Hungerbühler, Konrad; Baiker, Alfons; Tummala, Srinivas; Glennon, Brian; Kuentz, Martin; Steele, Gerry; Kramer, Herman J. M; Rydzak, James W.

Published on CMKC

Abstract

This multiauthor review article aims to bring readers up to date with some of the current trends in the field of process analytical technology (PAT) by summarizing each aspect of the subject (sensor development, PAT based process monitoring and control methods) and presenting applications both in industrial laboratories and in manufacture e.g. at GSK, AstraZeneca and Roche. Furthermore, the paper discusses the PAT paradigm from the regulatory science perspective. Given the multidisciplinary nature of PAT, such an endeavour would be almost impossible for a single author, so the concept of a multiauthor review was born. Each section of the multiauthor review has been written by a single expert or group of experts with the aim to report on its own Research Article results. This paper also serves as a comprehensive source of information on PAT topics for the novice reader.

Journal

Organic Process Research & Development. Volume 19, 2015, 3 -62

DOI

10.1021/op500261y

Type of publication

Peer-reviewed journal

Affiliations

  • BASF Schweiz AG / Budapest University of Technology and Economics
  • ETH Zürich / Bristol-Myers Squibb Company
  • University College Dublin / APC Ltd

Article Classification

Review article

Classification Areas

  • PAT
  • Oral solid dose
  • Modeling

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