Continuous crystallization of pharmaceuticals using a continuous oscillatory baffled crystallizer
Category
Published on CMKC
Abstract
In this paper, we report an investigation into the continuous crystallization of a model active pharmaceutical ingredient (API) using a continuous oscillatory baffled crystallizer (COBC). The results show that continuous crystallization offers significant advantages in terms of process, operation and costs, and delivers the isolation of the model API in just over 12 min compared to the 9 h and 40 min in a batch process. © 2009 American Chemical Society.
Journal
Organic Process Research & Development. Volume 13, 6, 2009, 1357-1363
DOI
10.1021/op900237x
Type of publication
Peer-reviewed journal
Affiliations
- Heriot-Watt University
- AstraZeneca
- Nitech Solutions
Article Classification
Research Article
Classification Areas
- Control