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Continuous crystallization of pharmaceuticals using a continuous oscillatory baffled crystallizer

By Lawton, Simon; Steele, Gerry Shering, Phil Zhao, Lihua; Laird, Ian; Ni,; Xiong Wei

View Resource (DOI)

Category

Peer-reviewed journal

Published on

Abstract

In this paper, we report an investigation into the continuous crystallization of a model active pharmaceutical ingredient (API) using a continuous oscillatory baffled crystallizer (COBC). The results show that continuous crystallization offers significant advantages in terms of process, operation and costs, and delivers the isolation of the model API in just over 12 min compared to the 9 h and 40 min in a batch process. © 2009 American Chemical Society.

Journal

Organic Process Research & Development. Volume 13, 6, 2009, 1357-1363

DOI

10.1021/op900237x

Type of publication

Peer-reviewed journal

Affiliations

  • Heriot-Watt University
  • AstraZeneca
  • Nitech Solutions

Article Classification

Research Article

Classification Areas

  • Control

Tags

  1. Continuous Oscillatory baffled reactors
  2. Control
  3. crystallization
  4. operation & cost
  5. Research Article