Continuous processing and production in pharmaceutical manufacturing has received increased attention in recent years mainly due to the industries’ pressing needs for more efficient, cost-effective processes and production, as well as regulatory facilitation. To achieve optimum product quality, the traditional trial-and-error method for the optimization of different process and formulation parameters is expensive and time consuming. Real-time evaluation and the control of product quality using an online process analyzer in continuous processing can provide high-quality production with very high-throughput at low unit cost. This review focuses on continuous processing and the application of different real-time monitoring tools used in the pharmaceutical industry for continuous processing from powder to tablets.

• National University of Singapore
• GEA Process Engineering N.V.

• PAT
• Oral solid dose

1. cost/benefit analysis
2. Drug Costs
3. Equipment Design
4. Online Systems
5. oral solid dose
6. pat
7. Pharmaceutical preparations
8. Quality control
9. Review article