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Continuous Processing in the Manufacture of Active Pharmaceutical Ingredients and Finished Dosage Forms: An Industry Perspective

By Poechlauer, P; Manley, JBroxterman, R; Gregertsen, B; Ridemark, M

Published on

Abstract

Continuous manufacturing as a way of producing fine chemicals, active pharmaceutical ingredients, and finished dosage forms is gaining widespread attention. Although potential benefits over traditional batch-wise production have been discussed at many occasions and appear evident, continuous processes are only slowly being implemented. The American Chemical Society Green Chemistry Institute Pharmaceutical Roundtable has defined “continuous processing” as one of its research priorities (1) and performed a survey of its members’ opinions, the status of implementation, and perceived hurdles blocking implementation of continuous manufacturing processes. Here we discuss the most important results of this survey and their relation to present trends in this industry to “go green”.

Journal

Organic Process Research & Development. Volume 16, 2012, 1586-1590

DOI

10.1021/op300159y

Type of publication

Peer-reviewed journal

Affiliations

  • DSM Innovative Synthesis BV
  • ACS Green Chemistry Institute
  • AstraZeneca R&D Sodertalje

Article Classification

Research Article

Classification Areas

  • API

Tags